8 CCl 4 generates highly reactive CCl 3 through the mediation of cytochrome p450, which leads to lipid peroxidation by stress, which eventually leads to hepatocellular damage. 4– 7 Carbon tetrachloride (CCl 4) is a common industrial solvent, cleaning agent, and a potent hepatotoxin, widely used in the laboratory to induce liver injury and fibrosis. 3 The main features of acute liver injury are necrosis, inflammatory cell infiltration, and apoptosis. 2 Acute liver damage from drugs, alcohol, and other substances is frequent, and severe liver damage often leads to liver failure and even death. 1 However, various external chemicals can damage this organ and cause chronic and acute liver disease. The liver is an essential organ for immunity and nutrition in animals and humans. This study provides a basis and new ideas for the development of functional foods or drugs related to the field of liver protection. Effervescent Tablet can be used as either a new formulation or practical product for patients who have difficulty swallowing regular tablets or capsules. In conclusion, LBB and LBBET may serve as potential mitigators of CCl 4-induced liver injury. In addition, LBB and LBBET may effectively alleviate CCl 4-induced liver injury by a mechanism related to the activation of the Nrf2 signaling pathway. Meanwhile, glutathione peroxidase, and superoxide dismutase levels were significantly increased in liver tissues. ![]() ![]() ![]() The results showed that LBB and LBBET pretreatment significantly reduced the serum levels of alanine aminotransferase, aspartate transaminase (AST), and alkaline phosphatase, as well as the liver tissue levels of malondialdehyde. ![]() In this study, we investigated the protective effects in rats of Lycium barbarum betaine (LBB) and Lycium barbarum betaine Effervescent Tablet (LBBET) against liver injury caused by carbon tetrachloride (CCl 4). Because of their low side effects and high safety, natural products have recently become a research hotspot for human health-related issues that can damage the liver. The liver is essential for animals and humans. All subjects Allied Health Cardiology & Cardiovascular Medicine Dentistry Emergency Medicine & Critical Care Endocrinology & Metabolism Environmental Science General Medicine Geriatrics Infectious Diseases Medico-legal Neurology Nursing Nutrition Obstetrics & Gynecology Oncology Orthopaedics & Sports Medicine Otolaryngology Palliative Medicine & Chronic Care Pediatrics Pharmacology & Toxicology Psychiatry & Psychology Public Health Pulmonary & Respiratory Medicine Radiology Research Methods & Evaluation Rheumatology Surgery Tropical Medicine Veterinary Medicine Cell Biology Clinical Biochemistry Environmental Science Life Sciences Neuroscience Pharmacology & Toxicology Biomedical Engineering Engineering & Computing Environmental Engineering Materials Science Anthropology & Archaeology Communication & Media Studies Criminology & Criminal Justice Cultural Studies Economics & Development Education Environmental Studies Ethnic Studies Family Studies Gender Studies Geography Gerontology & Aging Group Studies History Information Science Interpersonal Violence Language & Linguistics Law Management & Organization Studies Marketing & Hospitality Music Peace Studies & Conflict Resolution Philosophy Politics & International Relations Psychoanalysis Psychology & Counseling Public Administration Regional Studies Religion Research Methods & Evaluation Science & Society Studies Social Work & Social Policy Sociology Special Education Urban Studies & Planning BROWSE JOURNALS
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